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7 secrets Garcinia Cambogia
The prevalence of overweight has increased substantially in Japan during the past decade and it continues to rise. According to recent statistics, >30% of the Japanese adult population meets the current definition of overweight (body mass index [BMI] ≥25 kg/m2).1 Obesity is a problem not only in the Western world but also in Japan. It is well accepted that obesity is a risk factor for type 2 diabetes, coronary heart disease, and hypertension.2–13 Several studies, however, have shown that measurement of overall adiposity or body weight, such as with BMI, may not adequately describe the relationship of body fat to disease.14 It appears that visceral fat area (VFA) more fully explains this relationship.15,16 The clustering of hyperinsulinemia, dyslipidemia, type 2 diabetes mellitus, and hypertension is called the insulin resistance syndrome or metabolic syndrome, and syndrome X.17 Accordingly, evaluation of obesity for the prevention of syndrome X must be conducted using not only body weight or BMI but also VFA. Incidentally, it has been reported that a high-carbohydrate (sucrose) diet increases visceral fat accumulation in rats.18 Therefore, controlling the surplus energy from a high-carbohydrate diet is expected to be effective in preventing the accumulation of visceral fat.
Several studies have demonstrated that (-)-hydroxycitric acid (HCA), the principal acid of the rind of the Indian fruit Garcinia cambogia, is a competitive inhibitor of adenosine triphosphate citrate lyase,19–21 the enzyme that catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl coenzyme A. This action of HCA should reduce the acetyl coenzyme A pool, thus limiting the availability of 2-carbon units required for fatty acid and cholesterol biosynthesis.22 In vitro and in vivo studies show that HCA inhibits the actions of citrate cleavage enzyme, suppresses de novo fatty acid synthesis, increases rates of hepatic glycogen synthesis, and decreases body weight gain.23–27 In human studies, only supporting evidence exists for the efficacy of G cambogia in weight control, and it has yet to be assessed in relationship to visceral fat accumulation.
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The prevalence of overweight has increased substantially in Japan during the past decade and it continues to rise. According to recent statistics, >30% of the Japanese adult population meets the current definition of overweight (body mass index [BMI] ≥25 kg/m2).1 Obesity is a problem not only in the Western world but also in Japan. It is well accepted that obesity is a risk factor for type 2 diabetes, coronary heart disease, and hypertension.2–13 Several studies, however, have shown that measurement of overall adiposity or body weight, such as with BMI, may not adequately describe the relationship of body fat to disease.14 It appears that visceral fat area (VFA) more fully explains this relationship.15,16 The clustering of hyperinsulinemia, dyslipidemia, type 2 diabetes mellitus, and hypertension is called the insulin resistance syndrome or metabolic syndrome, and syndrome X.17 Accordingly, evaluation of obesity for the prevention of syndrome X must be conducted using not only body weight or BMI but also VFA. Incidentally, it has been reported that a high-carbohydrate (sucrose) diet increases visceral fat accumulation in rats.18 Therefore, controlling the surplus energy from a high-carbohydrate diet is expected to be effective in preventing the accumulation of visceral fat.
Several studies have demonstrated that (-)-hydroxycitric acid (HCA), the principal acid of the rind of the Indian fruit Garcinia cambogia, is a competitive inhibitor of adenosine triphosphate citrate lyase,19–21 the enzyme that catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl coenzyme A. This action of HCA should reduce the acetyl coenzyme A pool, thus limiting the availability of 2-carbon units required for fatty acid and cholesterol biosynthesis.22 In vitro and in vivo studies show that HCA inhibits the actions of citrate cleavage enzyme, suppresses de novo fatty acid synthesis, increases rates of hepatic glycogen synthesis, and decreases body weight gain.23–27 In human studies, only supporting evidence exists for the efficacy of G cambogia in weight control, and it has yet to be assessed in relationship to visceral fat accumulation.
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7 secrets Garcinia Cambogia